Sunday, May 20, 2007

Microwaves in Organic Synthesis

There are some good and recent reviews by Oliver Kappe (et al) on microwave-assisted organic synthesis:
1) "Microwave-Assisted Synthesis in Water as Solvent"; Chem Rev., 2007 (ASAP, DOI: 10.1021/cr0509410)

2) "The impact of microwave synthesis on drug discovery"; Nat Rev Drug Discov., 2006, 5(1), 51-63

3) "Controlled microwave heating in modern organic synthesis"; Angew Chem Int Ed Engl., 2004 , 43(46), 6250-84

I find them to be a useful guide to the microwave literature. The most recent review on water as a solvent is particularly interesting.